Andrew Wilkinson was a British politician and racehorse breeder.
He was the son of Charles Wilkinson of Boroughbridge and educated at Clare College, Cambridge and trained for the law at the Middle Temple.
A resident of Boroughbridge, he was returned in 1735 as Member of Parliament for Aldborough, succeeding his late father-in-law William Jessop. He would retain the seat until 1772, with the exception of the years 1765–1768, when he was displaced by Viscount Villiers. He was Storekeeper of the Ordnance from 1746 to 1762 and from 1765 to 1778.
By his marriage to Barbara Jessop, he inherited Broom Hall and had 7 sons. On his death in 1784, Broom hall was left to his eldest son, Rev. James Wilkinson. His third son, also named Andrew, became a captain in the Royal Navy.