William Drayton was an American politician, banker, and writer who grew up in Charleston, South Carolina. He was the son of William Drayton, Sr., who served as justice of the Province of East Florida.
Drayton served as a United States Representative to Congress. Following the Nullification Crisis, as a unionist Drayton decided to move his family to Philadelphia, Pennsylvania in 1833. He lived there the rest of his life. He was appointed as president of the Second Bank of the United States.